Enhances the articular chondrocytic phenotype, whereas it repressed the one representing endochondral ossification (PubMed: 21871891). Involved in bone regeneration as a negative regulator (By similarity). Seems to enhance bFGF-induced DNA synthesis in fibroblasts (PubMed: 15611078). Supports skin fibroblast adhesion through ITGA5:ITGB1 and ITGA6:ITGB1 and induces fibroblast chemotaxis through ITGAV:ITGB5. Also plays a role in cutaneous wound healing acting as integrin receptor ligand. In endothelial cells, supports cell adhesion, induces directed cell migration (chemotaxis) and promotes cell survival (PubMed: 12695522). Ligand of integrins ITGAV:ITGB3 and ITGA5:ITGB1, acts directly upon endothelial cells to stimulate pro-angiogenic activities and induces angiogenesis. Inhibits vascular smooth muscle cells proliferation by increasing expression of cell-cycle regulators such as CDKN2B or CDKN1A independently of TGFB1 signaling (PubMed: 20139355). Inhibits myogenic differentiation through the activation of Notch-signaling pathway (PubMed: 12050162). Essential regulator of hematopoietic stem and progenitor cell function (PubMed: 17463287). Acts by binding to integrins or membrane receptors such as NOTCH1 (PubMed: 12695522, 21344378, 15611078). Immediate-early protein playing a role in various cellular processes including proliferation, adhesion, migration, differentiation and survival (PubMed: 15181016, 15611078, 12695522, 21344378, 12050162). UniProtKB/Swiss-Prot Summary for CCN3 Gene
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